Plasma selenium concentration and prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition (EPIC).
نویسندگان
چکیده
BACKGROUND Some evidence indicates that a low selenium intake may be associated with an increased risk of prostate cancer. OBJECTIVE The aim of this study was to investigate the association of plasma selenium concentration with subsequent prostate cancer risk and to examine this association by stage and grade of disease and other factors. DESIGN A nested case-control study was performed among men in the European Prospective Investigation into Cancer and Nutrition (EPIC). The association between plasma selenium concentration and prostate cancer risk was assessed in 959 men with incident prostate cancer and 1059 matched controls. RESULTS Overall, plasma selenium concentration was not associated with prostate cancer risk; the multivariate relative risk for men in the highest fifth of selenium concentration compared with the lowest fifth was 0.96 (95% CI: 0.70, 1.31; P for trend = 0.25). There were no significant differences in the association of plasma selenium with risk when analyzed by stage or grade of disease. Similarly, the association of selenium with risk did not differ by smoking status or by plasma alpha- or gamma-tocopherol concentration. CONCLUSION Plasma selenium concentration was not associated with prostate cancer risk in this large cohort of European men.
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We appreciate the opportunity to respond to the letter from Drs Bekaert and Rayman regarding our recently published article (1) on the association between plasma selenium concentrations and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Bekaert and Rayman point out that the mean plasma selenium concentration of EPIC participants is lower than th...
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عنوان ژورنال:
- The American journal of clinical nutrition
دوره 88 6 شماره
صفحات -
تاریخ انتشار 2008